The three discrete symmetries of Quantum Mechanics, charge conjugation, parity, and time reversal, are all violated, singly or in pairs. CPT is the only combination of these symmetries which appears to be conserved in Nature. Even though this result is in agreement with the well known CPT theorem, that holds for standard quantum field theories, CPT violation in some cases might be expected and justified in the framework of a quantum theory of gravity. Here the last and more refined experimental searches for CPT violation effects will be reported with a special focus on the tests performed on neutral meson systems and the interplay between CPT symmetry and the basic principles of Quantum Mechanics. No deviation from the expectations of CPT symmetry and quantum mechanics is observed, while the precision of the measurements, in some cases, reaches the interesting Planck scale region. Finally, prospects for this kind of experimental studies will be presented.