In this talk, we will investigate the distinguishability of quantum operations from both discrete and continuous point of view. In the discrete case, the main topic is how we can identify quantum measurement apparatuses by considering the patterns of measurement outcomes. In the continuous case, we will focus on the efficiency of parameter estimation of quantum operations. We will discuss several methods that can achieve Heisenberg Limit and prove in some other cases the impossibility of breaking the Standard Quantum Limit. The general treatment of estimation of quantum operations also allows an investigation of the effect of noise on estimation efficiency.