Not only general relativity but also quantum theory plays important roles in current cosmology. Quantum fluctuations of matter fields are supposed to have provided the initial seeds of all the structure of the current universe, and quantum gravity is assumed to have been essential in the earliest stages. Both issues are not fully understood, although several heuristic effects have been discussed. In this talk, implications of an effective framework taking into account the coupling of matter and gravity are discussed. This touches on interpretational issues of quantum mechanics, cosmological observations and properties of quantum gravity.