The principles of Quantum Mechanics and of Classical General Relativity imply Uncertainty Relations between the different spacetime coordinates of the events, which yield to a basic model of Quantum Minkowski Space, having the full (classical) Poincare\' group as group of symmetries.
The four dimensional Euclidean distance is a positive operator bounded below by a constant of order one in Planck units; the area operator and the four volume operator are normal operators - the latter being a Lorentz invariant operator with pure point spectrum - whose moduli are also bounded below by a constant of order one. While the spectrum of the 3 volume operator includes zero.
These findings are in perfect agreement with the physical intuition suggested by the Spacetime Uncertainty Relations which are implemented by the Algebra of Quantum Spacetime.
The formulations of interactions between quantum fields on Quantum Spacetime will be discussed. The various approaches to interactions, equivalent to one another on the Minkowski background, yield to different schemes on Quantum Spacetime, with the common feature of a breakdown of Lorentz invariance due to interactions. In particular one of these schemes will be discussed and motivated, which leads to fully Ultraviolet-Finite theories.
Quantum fields will depend on the quantum coordinates, but, in presence of Gravity, the commutators of the coordinates might in turn depend on the quantum fields, giving rise to a quantum texture where fields and spacetime coordinates cannot be separated. Possible deep physical consequences will be outlined.